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1

Improvement in Wound Healing by Epidermal Growth Factor (EGF) Ointment. I. Effect of Nafamostat, Gabexate, or Gelatin on Stabilization and Efficacy of EGF

Katsuhiko Okumura, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa, Midori Hirai, Tohru Fuwa

Journal:

Pharmaceutical Research

Year:

1990

File:

PDF, 2.89 MB

1990

2

Chitosan Induces Apoptosis via Caspase-3 Activation in Bladder Tumor Cells

Masumi Hasegawa, Keiko Yagi, Seigo Iwakawa, Midori Hirai

Journal:

Year:

2001

Language:

english

File:

PDF, 1.33 MB

english, 2001

3

Intratracheal delivery of insulin Absorption from solution and aerosol by rat lung

Katsuhiko Okumura, Seigo Iwakawa, Tsuguchika Yoshida, Toshimitsu Seki, Fusao Komada

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 708 KB

english, 1992

4

Prolonged circulation of menatetrenone by emulsions with hydrogenated castor oils in rats

Kumiko Ueda, Takashi Furukawa, Yuriko Kawaguchi, Yosuke Miki, Toshiyuki Sakaeda, Seigo Iwakawa

Journal:

Journal of Controlled Release

Year:

2004

Language:

english

File:

PDF, 450 KB

english, 2004

5

Effect of Particle Size on the Pharmacokinetics of Menatetrenone Incorporated in O/W Lipid Emulsions Prepared with Hydrogenated Castor Oils and Soybean Oil in Rats

Ueda, Kumiko, Yamazaki, Yuka, Teshima, Yasuko, Yamashita, Chiharu, Sakaeda, Toshiyuki, Iwakawa, Seigo

Journal:

Journal of Drug Targeting

Year:

2003

Language:

english

File:

PDF, 206 KB

english, 2003

6

Intratracheal delivery of peptide and protein agents: Absorption from solution and dry powder by rat lung

Fusao Komada, Seigo Iwakawa, Nakayuki Yamamoto, Hideo Sakakibara, Katsuhiko Okumura

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 498 KB

english, 1994

7

Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism*

Okumura, Katsuhiko, Kita, Tomoko, Chikazawa, Shinji, Komada, Fusao, Iwakawa, Seigo, Tanigawara, Yusuke

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 1.62 MB

english, 1997

8

Enhanced Anti-Inflammatory Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts In Vitro and In Vivo

Katsuhiko Okumura, Kohshi Nishiguchi, Yusuke Tanigawara, Sachiko Mori, Seigo Iwakawa, Fusao Komada

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 544 KB

1997

9

Characterization of Epidermal Growth Factor Receptors on Plasma Membranes Isolated from Rat Gastric Mucosa

Ryohei Hori, Hisashi Nomura, Seigo Iwakawa, Katsuhiko Okumura

Journal:

Pharmaceutical Research

Year:

1990

File:

PDF, 1.03 MB

1990

10

Enhanced Bioavailability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease Inhibitors

Masaharu Takeyama, Toshihiko Ishida, Noriko Kokubu, Fusao Komada, Seigo Iwakawa, Katsuhiko Okumura, Ryohei Hori

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 841 KB

1991

11

Effects of Transfection with the Cu, Zn-Superoxide Dismutase Gene on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Fibroblasts from Rat Skin

Kohshi Nishiguchi, Kazue Ishida, Masanori Nakajima, Tetsuo Maeda, Fusao Komada, Seigo Iwakawa, Yusuke Tanigawara, Katsuhiko Okumura

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.18 MB

1996

12

Effect of Epidermal Growth Factor on Cu, Zn-Superoxide Dismutase Expression in Cultured Fibroblasts from Rat Skin

Kohshi Nishiguchi, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa, Katsuhiko Okumura

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 1.32 MB

1994

13

Effect of acyl chains of phosphatidylcholines on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with phosphatidylcholines and soybean oil in rats

Kumiko Ueda, Masanori Fujimoto, Hiromi Noto, Toshiyuki Sakaeda, Seigo Iwakawa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 125 KB

english, 2004

14

Effect of oxyethylene moiety in polyoxyethylene sorbitan esters on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with polyoxyethylene sorbitan esters and soybean oil in rats

Kumiko Ueda, Masanori Fujimoto, Hiromi Noto, Yuriko Kawaguchi, Toshiyuki Sakaeda, Seigo Iwakawa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 199 KB

english, 2002

15

Effect of oil-in-water lipid emulsions prepared with fish oil or soybean oil on the growth of MCF-7 cells and HepG2 cells

Kumiko Ueda, Yukiko Asai, Yoshimizu Yoshimura, Seigo Iwakawa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 418 KB

english, 2008

16

Procedures to CharacterizeIn VivoandIn VitroEnantioselective Glucuronidation Properly: Studies with Benoxaprofen Glucuronides

Hildegard Spahn, Seigo Iwakawa, Emil T. Lin, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

1989

File:

PDF, 1.39 MB

1989

17

Enhanced Bioavailability of Subcutaneously Injected Insulin Coadministered with Collagen in Rats and Humans

Ryohei Hori, Fusao Komada, Seigo Iwakawa, Yutaka Seino, Katsuhiko Okumura

Journal:

Pharmaceutical Research

Year:

1989

File:

PDF, 655 KB

1989

18

Specific secretin binding sites in rat pancreas

Okumura Katsuhiko, Iwakawa Seigo, Inui Ken-Ichi, Hori Ryohei

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 670 KB

english, 1983

19

Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin

Iwakawa Seigo, Hildegard Spahn, Leslie Z. Benet, Emil T. Lin

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 554 KB

english, 1990

20

Predictability of the covalent binding of acidic drugs in man

Leslie Z. Benet, Hildegard Spahn-Langguth, Seigo Iwakawa, Christine Volland, Takashi Mizuma, Sascha Mayer, Ernst Mutschler, Emil T. Lin

Journal:

Year:

1993

Language:

english

File:

PDF, 364 KB

english, 1993

21

Effect of Injection Volume on the Pharmacokinetics of Oil Particles and Incorporated Menatetrenone after Intravenous Injection as O/W Lipid Emulsions in Rats

Ueda, Kumiko, Ishida, Mizuki, Inoue, Tomoko, Fujimoto, Masanori, Kawahara, Yuko, Sakaeda, Toshiyuki, Iwakawa, Seigo

Journal:

Journal of Drug Targeting

Year:

2001

Language:

english

File:

PDF, 630 KB

english, 2001

22

Effect of Oxyethylene Moieties in Hydrogenated Castor Oil on the Pharmacokinetics of Menatetrenone Incorporated in O/W Lipid Emulsions Prepared with Hydrogenated Castor Oil and Soybean Oil in Rats

Ueda, Kumiko, Yamazaki, Yuka, Noto, Hiromi, Teshima, Yasuko, Yamashita, Chiharu, Sakaeda, Toshiyuki, Iwakawa, Seigo

Journal:

Journal of Drug Targeting

Year:

2003

Language:

english

File:

PDF, 158 KB

english, 2003

23

Usefulness of glycated albumin in decisions regarding the discontinuation of a diabetes drug and factors associated with poor glycemic control following discontinuation in patients with type 2 diabetes mellitus

Masumoto, Norio, Otsuki, Hiroaki, Iwakawa, Seigo, Inada, Shinya, Koga, Masafumi

Journal:

Diabetology International

Year:

2017

Language:

english

File:

PDF, 452 KB

english, 2017

24

Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells

Tanaka, Shota, Hosokawa, Mika, Ueda, Kumiko, Iwakawa, Seigo

Year:

2015

Language:

english

File:

PDF, 674 KB

english, 2015

25

Cytoprotective Effects of Epidermal Growth Factor (EGF) Ointment Containing Nafamostat, a Protease Inhibitor, on Tissue Damage at Burn Sites in Rats.

KIYOHARA, Yoshifumi, NISHIGUCHI, Kohshi, KOMADA, Fusao, IWAKAWA, Seigo, HIRAI, Midori, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1993

File:

PDF, 745 KB

1993

26

Systemic Effects of Epidermal Growth Factor (EGF) Ointment Containing Protease Inhibitor or Gelatin in Rats with Burns or Open Wounds.

KIYOHARA, Yoshifumi, KOMADA, Fusao, IWAKAWA, Seigo, FUWA, Tohru, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1993

File:

PDF, 639 KB

1993

27

Population Pharmacokinetics of Theophylline. III. Premarketing Study for a Once-Daily Administered Preparation.

TANIGAWARA, Yusuke, KOMADA, Fusao, SHIMIZU, Takako, IWAKAWA, Seigo, IWAI, Tetsushi, MAEKAWA, Hiroumi, HORI, Ryohei, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1995

File:

PDF, 1.30 MB

1995

28

Transport Mechanism of Anthracycline Derivatives in Rat Polymorphonuclear Leukocytes: Uptake and Efflux of Pirarubicin.

NAGASAWA, Kazuki, NOMIYAMA, Masako, OHNISHI, Noriaki, YOKOYAMA, Teruyoshi, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1994

File:

PDF, 859 KB

1994

29

Transport Mechanism of Anthracycline Derivatives in Rat Polymorphonuclear Leukocytes: Uptake of Pirarubicin, Daunorubicin and Doxorubicin.

NAGASAWA, Kazuki, NOMIYAMA, Masako, OHNISHI, Noriaki, YOKOYAMA, Teruyoshi, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1994

File:

PDF, 673 KB

1994

30

Effect of Clarithromycin on the Bioavailability of Cyclosporin in Rats.

OHBA, Makiko, OHNISHI, Noriaki, KOMADA, Fusao, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1996

File:

PDF, 799 KB

1996

31

Effect of Transfection with a Superoxide Dismutase Expression Plasmid on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Cultured Rat Lung Cells.

KOMADA, Fusao, NISHIGUCHI, Kohshi, TANIGAWARA, Yusuke, WU, Xiao-Ying, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1996

File:

PDF, 568 KB

1996

32

Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts on Cold-Induced Skin Edema in Rats.

NISHIGUCHI, Kohshi, KOMADA, Fusao, TANIGAWARA, Yusuke, SAKAI, Yumiko, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1998

File:

PDF, 549 KB

1998

33

Protective Effect of Transfection with Secretable Superoxide Dismutase (SOD) (a Signal Sequence-SOD Fusion Protein Coding cDNA) Expression Vector on Superoxide Anion-Induced Cytotoxicity in Vitro.

KOMADA, Fusao, NISHIGUCHI, Kohshi, TANIGAWA, Yasuke, ISHIDA, Mariko, WU, Xiao-Ying, IWAKAWA, Seigo, SASADA, Reiko, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1997

File:

PDF, 1.01 MB

1997

34

N-Acetyltransferase2 Genotype Correlated with Isoniazid Acetylation in Japanese Tuberculous Patients.

KITA, Tomoko, TANIGAWARA, Yusuke, CHIKAZAWA, Shinji, HATANAKA, Hisakatsu, SAKAEDA, Toshiyuki, KOMADA, Fusao, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

2001

Language:

english

File:

PDF, 90 KB

english, 2001

35

Effects of Secretable SOD Delivered by Genetically Modified Cells on Xanthine/Xanthine Oxidase and Paraquat-Induced Cytotoxicity in Vitro.

KOMADA, Fusao, NISHIGUCHI, Kohshi, TANIGAWARA, Yusuke, IWAKAWA, Seigo, OKUMURA, Katsuhiko

Journal:

Biological & Pharmaceutical Bulletin

Year:

1999

File:

PDF, 1.29 MB

1999

36

Effect of Glimepiride and Glibenclamide on S-Warfarin 7-Hydroxylation by Human Liver Microsomes, Recombinant Human CYP2C9.1 and CYP2C9.3

Iwakawa, Seigo, Miyashita, Kenji, Hashimoto, Yasuaki, Kuroda, Tsutomu

Journal:

Biological & Pharmaceutical Bulletin

Year:

2006

Language:

english

File:

PDF, 94 KB

english, 2006

37

Effect of 2-Methoxyestradiol, Buthionine Sulfoximine and Hydrogen Peroxide on the Viability of Renal Carcinoma Cell Lines (ACHN and ACVB)

Hirai, Yuka, Kawabe, Noriko, Tsuda, Yoshiko, Miyamoto, Satoru, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

38

Effect of Ethanol on S-Warfarin and Diclofenac Metabolism by Recombinant Human CYP2C9.1

Tatsumi, Akitoshi, Ikegami, Yuki, Morii, Ryoko, Sugiyama, Masatoshi, Kadobayashi, Muneo, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2009

Language:

english

File:

PDF, 65 KB

english, 2009

39

Effect of Oxyethylene Numbers on the Pharmacokinetics of Menatetrenone Incorporated in Oil-in-Water Lipid Emulsions Prepared with Polyoxyethylene–Polyoxypropylene Block Copolymers and Soybean Oil in Rats

Ueda, Kumiko, Kawaguchi, Yuriko, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2008

Language:

english

File:

PDF, 98 KB

english, 2008

40

Erratum: Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients [Biol. Pharm. Bull. 32(2): 304—307]

Igarashi, Tsutomu, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2009

Language:

english

File:

PDF, 21 KB

english, 2009

41

Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients

Igarashi, Tsutomu, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2009

Language:

english

File:

PDF, 88 KB

english, 2009

42

Different Involvement of DNA Methylation and Histone Deacetylation in the Expression of Solute-Carrier Transporters in 4 Colon Cancer Cell Lines

Ikehata, Mika, Ueda, Kumiko, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

43

Induction of Epithelial-Mesenchymal Transition and Down-Regulation of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells

Tanaka, Shota, Hosokawa, Mika, Yonezawa, Takeshi, Hayashi, Wataru, Ueda, Kumiko, Iwakawa, Seigo

Year:

2015

Language:

english

File:

PDF, 555 KB

english, 2015

44

Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells

Ueda, Kumiko, Hosokawa, Mika, Iwakawa, Seigo

Year:

2015

Language:

english

File:

PDF, 720 KB

english, 2015

45

Different Effects of Epigenetic Modifiers on the Cytotoxicity Induced by 5-Fluorouracil, Irinotecan or Oxaliplatin in Colon Cancer Cells

Ikehata, Mika, Ogawa, Mao, Yamada, Yasuki, Tanaka, Shota, Ueda, Kumiko, Iwakawa, Seigo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2014

Language:

english

File:

PDF, 518 KB

english, 2014

46

Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa: Effect of Fasting and Sialoadenectomy.

OKUMURA, Katsuhiko, NOMURA, Hisashi, IWAKAWA, Seigo, HORI, Ryohei

Journal:

Journal of Pharmacobio-Dynamics

Year:

1991

File:

PDF, 1001 KB

1991

47

Direct Modulation of Secretin Binding Sites by Gastrin in the Rat Stomach.

IWAKAWA, Seigo, NOMURA, Hisashi, HORI, Ryohei, OKUMURA, Katsuhiko

Journal:

Journal of Pharmacobio-Dynamics

Year:

1992

File:

PDF, 582 KB

1992

48

Pharmacokinetics of pirarubicin in pediatric patients.

NAGASAWA, Kazuki, YOKOYAMA, Teruyoshi, OHNISHI, Noriaki, IWAKAWA, Seigo, OKUMURA, Katsuhiko, KOSAKA, Yoshiyuki, SANO, Kimihiko, MURAKAMI, Ryusuke, NAKAMURA, Hajime

Journal:

Journal of Pharmacobio-Dynamics

Year:

1991

File:

PDF, 819 KB

1991

49

Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa: Effect of Gastric Ulceration.

NOMURA, Hisashi, IWAKAWA, Seigo, SAITO, Yoshihiro, HORI, Ryohei, OKUMURA, Katsuhiko

Journal:

Journal of Pharmacobio-Dynamics

Year:

1991

File:

PDF, 656 KB

1991

50

Pharmacokinetics of Zonisamide; Saturable Distribution into Human and Rat Erythrocytes and into Rat Brain.

NISHIGUCHI, Kohshi, OHNISHI, Noriaki, IWAKAWA, Seigo, YAGI, Jiro, NAKAYAMA, Shinichi, TAKADA, Satoshi, NAKAMURA, Hajime, YOKOYAMA, Teruyoshi, OKUMURA, Katsuhiko

Journal:

Journal of Pharmacobio-Dynamics

Year:

1992

File:

PDF, 756 KB

1992